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Cytokines 2024 KAI 2024

    
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Day 3
October 22(Tue)
08:30-10:10
Symposium 12

Engineered Cytokine and Immunotherapy

Room A
Chair(s) Brendan Jenkins (The University of Adelaide, AUS)
Yoon Park (Korea Institute of Science and Technology, KOR)
08:30-08:55 Molecular modulation of interleukin-2 for next-generation immunotherapy

Onur Boyman (Univ. of Zurich, CHE)

Abstract
08:55-09:20 Unraveling the mystery of IFNλ4 and its signaling complex utilizing computation, protein engineering, and cryoEM

Juan Mendoza (Univ Chicago, USA)

Abstract
09:20-09:45 New strategies of antibody based fusion proteins for tumor immunity

Yang-Xin Fu (Tsinghua Univ., CHN)

Abstract
09:45-09:57 STAT Rebalancing with Engineered Cytokines Restrains T Cell Exhaustion and Mitigates Toxicity

Grayson Rodriguez (Stanford University, USA)

Abstract
09:57-10:09 AttIL12-T Cell Therapy For Simultaneously Disrupting Stroma/tumors And Induction Of Endogenous TCR-T Cells

Shulin Li (The University of Texas MD Anderson Cancer Center, USA)

Abstract
October 22(Tue)
08:30-10:10
Symposium 13

Immune Regulation of Inflammatory Diseases (Partly Sponsored by Elsevier's Journal Cytokine)

Room B
Chair(s) Dhan Kalvakolanu (University of Maryland School of Medicine, USA)
Chang Ook Park (Yonsei University College of Medicine, KOR)
08:30-08:55 Transcription factor NFAT5 is essential to rheumatoid arthritis

Wan-Uk Kim (Catholic Univ., KOR)

Abstract
08:55-09:20 Metabolic checkpoints in autoimmune tissue inflammation

Cornelia M. Weyand (Mayo Clinic, USA)

Abstract
09:20-09:45 Mechanistic insights into glucocorticoid regulation of immune responsiveness at the MIF locus

Richard J. Bucala (Yale Univ. School of Medicine, USA)

Abstract
09:45-09:57 Cytokine and metabolic regulation of tissue Tregs at homeostasis and during obesity-associated inflammatory and metabolic diseases (2024 ICIS-Regeneron New Investigator Awards for Excellence in Cytokine & Interferon Research)

Chaoran Li (Emory University, USA)

Abstract
09:57-10:09 IL-38 Is A Novel Inhibitor Of The Pattern Recognition Receptor-Interferon Axis

Ina Rudloff (Hudson Institute of Medical Research, AUS)

Abstract
October 22(Tue)
08:30-10:10
Guest symposium 2

Stress Immune Responses and Homeostasis (by Japanese Cytokines Society)

Room C
Chair(s) Hiroki Yoshida (Saga University Faculty of Medicine, JPN)
Akinori Takaoka (Hokkaido University, JPN)
08:30-08:40 Introduction of JCS

Toshiaki Ohteki (Tokyo Medical and Dental University, JPN)

Abstract
08:40-08:58 Immune response in the central nervous system disease

Minako Ito (Medical Institute of Bioregulation Kyushu University, JPN)

Abstract
08:58-09:16 Generation and behavior of innate immune cells during systemic infection

Masashi Kanayama (Medical Research Institute, Tokyo Medical and Dental University, JPN)

Abstract
09:16-09:34 Memory CD8 T cells are vulnerable to chronic interferon-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice

Ruka Setoguchi (The University of Tokyo, JPN)

Abstract
09:34-09:52 Spatial diversity of the liver immune function and its significance

Yu Miyamoto (Osaka University Immunology Frontier Research Center, JPN)

Abstract
09:52-10:10 Mechanisms of colitis prevention following cecal resection

Kazuyo Moro (Osaka University, RIKEN, JPN)

Abstract
October 22(Tue)
10:10-10:40
Coffee Break

October 22(Tue)
10:40-12:00
Symposium 14

Cytokines and CD8 T Cell Immunity (Partly Sponsored by Trutino Biosciences)

Room A
Chair(s) David G Brooks (Univ. of Toronto, CAN)
Sang-Jun Ha (Yonsei University, KOR)
10:40-11:05 Retinoic acid and TGF-β orchestrate organ-specific programs of tissue-residency

Laura Mackay (2024 ICIS-Luminex John R. Kettman Award for Excellence in Cytokine & Interferon Research
Univ. of Melbourne, AUS)

Abstract
11:05-11:30 Costimulation modulates exhausted PD-1+ CD8 T cells beyond priming

Alice Kamphorst (Mount Sinai, USA)

Abstract
11:30-11:55 T cell differentiation and function in chronic infection and cancer

Axel Kallies (Univ. of Melbourne, AUS)

October 22(Tue)
10:40-12:00
Symposium 15

Cytokines and Myeloid Cells

Room B
Chair(s) Ivan Zanoni (Harvard Medical School, USA)
Keehoon Jung (Seoul National University, KOR)
10:40-11:05 Spatial and molecular control of tumor-associated macrophages

Renato Ostuni (Università Vita-Salute San Raffaele, ITA)

Abstract
11:05-11:17 Age-dependent inflammation is promoted by GDF3-SMAD2/3 signaling axis in adipose tissue macrophages (2024 ICIS-Pfizer Trainee Award)

In Hwa Jang (University of Minnesota, USA)

Abstract
11:17-11:42 Microbiota-regulation of tumor-associated macrophages

Jorge Henao-Mejia (Univ. of Pennsylvania, USA)

Abstract
11:42-11:54 Cancer Neutrophil Encyclopedia: A Deep Dive into Antigen-Presenting Warriors (2024 Sidney & Joan Pestka Graduate Award)

Ying Cheng Wu (Zhongshan Hospital Fudan University, CHN)

Abstract
October 22(Tue)
10:40-12:00
Symposium 16

Immune Regulation of Tissue Repair (Co-hosted by the Innate Immune-Mediated Chronic Inflammatory Disease Medical Research Center)

Room C
Chair(s) Snehlata Kumari (The University of Queensland, AUS)
YunJae Jung (Gachon University, KOR)
10:40-11:05 Fibroblast orchestration of tissue resident lymphocytes in disease and aging

Tien Peng (Univ. of California, San Francisco, USA)

Abstract
11:05-11:30 Unique mechanisms of early life inflammation

Shruti Naik (New York Univ., USA)

Abstract
11:30-11:42 Inflammatory niche in lung tissue regeneration and chronic diseases

Jinwook Choi (Gwangju Institute of Science and Technology (GIST), KOR)

Abstract
11:42-11:54 Tif1g regulates stability of regulatory T cells during inflammation (2024 ICIS-Pfizer Trainee Award)

Eugenio Contreras Castillo (National Autonomous University of Mexico, MEX)

Abstract
October 22(Tue)
12:00-13:00
Lunch Break

October 22(Tue)
13:00-14:30
Poster 3

October 22(Tue)
14:30-15:20
Lightning Talks 4

Tumor Immunology and Immunotherapy (Partly Sponsored by Regeneron)

Room A
Chair(s) Eva Conde Garcia (Regeneron Pharmaceuticals, USA)
Sejin Im (Sungkyunkwan University School of Medicine, KOR)
14:30-14:38 Enabling Immune Checkpoint Blockade Efficacy in T-lymphopenia by Restoring CD8 T cell Dynamics with IL-7 Cytokine Therapy

Yeon-Woo Kang (POSTECH, KOR)

Abstract
14:38-14:46 Targeting Nrf2 Enhances Anti-tumour Immune Response of CAR-T cells

Yuna Jo (Pusan National University School of Medicine, KOR)

Abstract
14:46-14:54 Infectious Bursal Disease Virus (IBDV) as a novel virotherapy for stimulating innate and adaptive immune responses in different murine cancer models.

Vicent Tur Planells (CEU San Pablo University, Spain)

Abstract
14:54-15:02 IL-9 Promotes Lung Tumor Growth by Intrinsic Regulation of Interstitial Macrophage Arginine Metabolism

Anthony Cannon (Indiana University School of Medicine, USA)

Abstract
15:02-15:10 Biological Mechanisms of IL-15 and IL-21-Augmented CAR T-Cell Therapy for Neuroblastoma

Natalia Yakobian (National Cancer Institute, USA)

Abstract
15:10-15:18 Tailoring T cell anti-tumor immunity in hepatocellular carcinoma by exploiting Kupffer cell-guided priming

Jaeoh Park (University of Lausanne, Switzerland)

Abstract
October 22(Tue)
14:30-15:20
Lightning Talks 5

Innate Immunity in Health and Diseases

Room B
Chair(s) Claudia Nold-Petry (The Ritchie Centre, Hudson Institute of Medical Research, Melbourne VIC, AUS)
Je-Wook Yu (Yonsei University, KOR)
14:30-14:38 Cholesterol metabolism in dendritic cells regulates neutrophilic asthma by controlling ER stress-PPARg balance

HAYEON CHUNG (Seoul National University, KOR)

Abstract
14:38-14:46 Dissecting The Role of Myeloid-Derived NLRP3 in a Murine Model of Silicosis

Kristian Barry (Hudson Institute of Medical Research, AUS)

Abstract
14:46-14:54 Regnase-1/3 controls hematopoietic lineage bias through degradation of Nfkbiz mRNA

Takuya Uehata (Graduate School of Medicine, Kyoto university, JPN)

Abstract
14:54-15:02 STK25 Regulates Myeloid Cell Trafficking and Effector Function during Injury and Inflammation

Bharati Matta (The Feinstein Institutes for Medical Research, Northwell Health, USA)

Abstract
15:02-15:10 Impact of cAMP reduction in myeloid cells on gut dysbiosis-induced attenuation of influenza virus immunity

Seongok Park (Jeonbuk National University, KOR)

Abstract
15:10-15:18 Bacterial and age-dependent inflammatory responses in BMDMs coinfected with Influenza virus and Streptococcus sp.

Extanislao Nistal Villan (Universidad San Pablo CEU, Spain)

Abstract
October 22(Tue)
14:30-15:20
Lightning Talks 6

Immune Regulation of Inflammatory Diseases

Room C
Chair(s) Kiyoshi Hirahara (Graduate School of Medicine, Chiba University, JPN)
Yoon-Seok Chang (Seoul National University Budang Hospital, KOR)
14:30-14:38 Intermittent Fasting Alleviates ILC2-mediated Type 2 Airway Inflammation

Young Jin Pyung (Seoul National University, KOR)

Abstract
14:38-14:46 Interferon Regulatory Factor 6 Determines Intestinal Epithelial Cell Development and Immunity

Austin Wright (Oregon Health & Science University, USA)

Abstract
14:46-14:54 Targeting the PD-1-FABP5 Axis Modulates Adipose Tissue ILC2 Metabolism in Obesity

Jongho Ham (Seoul National University, KOR)

Abstract
14:54-15:02 Ikzf1 Association With Foxp3 For Foxp3-dependent Gene Repression In Treg Cells: Disruption Of The Association Causes Autoimmunity

Kenji Ichiyama (Osaka University, JPN)

Abstract
15:02-15:10 Epithelial NF-kB coordinates type-17 immunity to initiate chronic inflammatory skin disease

Snehlata Kumari (The University of Queensland, AUS)

Abstract
15:10-15:18 Elucidating the Role of IFIH1 in Lupus Nephritis Pathogenesis

Jacquelyn Gorman (Oklahoma Medical Research Foundation, USA)

Abstract
October 22(Tue)
15:20-15:50
Industry 3

Emerging Therapeutics in Autoimmune Diseases (Abbvie)

Room A
Chair(s) Seung Cheol Shim (Chungnam National University, KOR)
15:20-15:50 JAK signaling in B cell activation and autoimmunity

Jason Jungsik Song (Yonsei University, KOR)

Abstract
October 22(Tue)
15:20-15:50
Industry 4

Tacrolimus and Autoimmune: From Mechanism to Clinical Practice (Astellas)

Room B
Chair(s) Jaeseok Yang (Yonsei University College of Medicine, Severance Hospital, KOR)
15:20-15:50 Mode of action of tacrolimus an autoimmune disease

Young Jae Park (Seoul St.Mary’s hospital, KOR)

Abstract
October 22(Tue)
15:50-16:20
Coffee Break

October 22(Tue)
16:20-18:00
Symposium 17

Type 2 Immunity and Airway Diseases (Partly Sponsored by the Society of Mucosal Immunology, SMI)

Room A
Chair(s) Elia Tait Wojno (University of Washington, USA)
Hyun-Woo Shin (Seoul National University, KOR)
16:20-16:45 Tfh cells and the antibody response to food allergens

Stephanie Eisenbarth (Northwestern Univ., USA)

Abstract
16:45-17:10 ILCs at the crossroads: understanding their influence in type 2 immunity and airway disorders

Hye-Young Kim (Seoul National Univ., KOR)

Abstract
17:10-17:35 The regulation and role lung resident and lymphoid T follicular helper cells in allergic airways disease

James Harker (Imperial College London, GBR)

17:35-17:47 Myeloid derived CXCL4 is required for optimal neutrophil recruitment into the lung during pulmonary allergic inflammation (2024 Pfizer-Amanda Proudfoot Tribute Award for Advances in Chemokine Biology by a Trainee)

Amanda Ridley (The University of Manchester, GBR)

Abstract
17:47-17:59 Th2 Cytokines Contribute to EoE Pathogenesis by Initiating STAT3/6-Mediated Mitochondria-Immune Signaling Axis

Jazmyne Jackson (Temple University, USA)

Abstract
October 22(Tue)
16:20-18:00
Symposium 18

Clinical Immunology of Autoimmune Diseases

Room B
Chair(s) Daniella Schwartz (University of Pittsburgh, USA)
Seung-Ki Kwok (Seoul St. Mary's Hospital, The Catholic University of Korea, KOR)
16:20-16:45 Mechanism-based cytokine-targeting therapies and precision medicine in rheumatic diseases

Yoshiya Tanaka (Univ. of Occupational and Environmental Health, JPN)

Abstract
16:45-17:10 The role of cytokine receptors in identifying T cell subsets in health and disease

Insoo Kang (Yale Univ. School of Medicine, USA)

Abstract
17:10-17:35 Integrative functional genomics reveals the determinants of Age/autoimmune-associated B Cells (ABCs)

Nan Shen (Shanghai Jiao Tong Univ. School of Medicine, CHN)

Abstract
17:35-17:47 RNA Host Response Profiling and Machine Learning for Differential Diagnosis of Acute Inflammatory Syndromes

Venice Servellita (University of California San Francisco, USA)

Abstract
17:47-17:59 IL-6 and IL-27 offer new insights into the development of disease heterogeneity in rheumatoid arthritis

Simon Jones (The School of Medicine, Cardiff University, GBR)

Abstract
October 22(Tue)
16:20-18:00
Guest Symposium 3

Lambda IFN

Room C
Chair(s) Ivan Zanoni (Harvard Medical School, USA)
Steeve Boulant (University of Florida, USA)
16:20-16:45 IFN-λ controls intestinal repair in IBD

Achille Broggi (CIML, FRA)

Abstract
16:45-17:10 Type III interferons (IFNλs) control intestinal epithelial barrier functions

Megan Stanifer (Univ. of Florida, USA)

Abstract
17:10-17:35 Single cell sequencing of influenza virus infected primary human alveolar macrophages reveals a powerful Interferon Lambda response

Rune Hartmann (Aarhus Univ., DNK)

Abstract
17:35-17:47 Viral exploitation of the programmed cell death for evasion of IFN-Lambda immunity

Sanghyun Lee (Brown Univ., USA)

Abstract
17:47-17:59 Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda

Tim Nice (OHSU, USA)

Abstract

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