Skip Navigation
Skip to contents

Cytokines 2024 KAI 2024

    
Search
Day
October 20(Sun)
13:00-14:40
Opening Session & Award Ceremony

Room A
Chair(s) You-Me Kim (KAIST, KOR)
Christopher Hunter (University of Pennsylvania, USA)
13:00-13:05 Welcome Address 1

13:05-13:10 Welcome Address 2

13:10-13:15 Presentation of ICIS Honorary Membership Award

13:15-13:20 Presentation of 2024 ICIS-Luminex John R. Kettman Award for Excellence in Cytokine & Interferon Research Mid-Career

13:20-13:30 KAI Award Ceremony

13:30-13:40 ICIS Award Ceremony

13:40-14:07 An overview of the field of monogenic diseases associated with enhanced type I interferon signalling, with an emphasis on more recent points of interest (2024 ICIS-Pfizer Award for Excellence in Interferon and Cytokine Research)

Yanick Joseph Crow (2024 ICIS-Pfizer Award for Excellence in Interferon and Cytokine Research
Univ. of Edinburgh, GBR)

Abstract
14:07-14:37 The complex biology of interleukin-6: therapeutic concepts (2024 ICIS-BioLegend William E. Paul Award)

Stefan Rose-John (2024 ICIS-BioLegend William E. Paul Award
Christian Albrecht Univ., Kiel Institute of Biochemistry Kiel, DEU)

Abstract
October 20(Sun)
14:40-15:10
Coffee Break

October 20(Sun)
15:10-16:50
Jürg Tschopp Memorial Symposium 1

IFNs and Inflammation

Room A
Chair(s) Yoichiro Iwakura (The University of Tokyo, JPN)
Jeon-Soo Shin (Yonsei University College of Medicine, KOR)
15:10-15:35 Positive and negative regulation of interferon antiviral signaling

Curt Horvath (Northwestern Univ., USA)

Abstract
15:35-16:00 Molecular mechanisms of innate immunity and inflammation in health and disease

Thirumala-Devi Kanneganti (St. Jude Children's Hospital, USA)

Abstract
16:00-16:25 Interferon-mediated regulation of cancer immunity and immunotherapy

David G Brooks (Univ. of Toronto, CAN)

Abstract
16:25-16:37 N4BP1 coordinates IKK family crosstalk to limit inflammation (2024 ICIS-Regeneron New Investigator Awards for Excellence in Cytokine & Interferon Research)

Alexander Gitlin (Memorial Sloan Kettering Cancer Center, USA)

Abstract
16:37-16:49 Human IFNs Transcriptomic Atlas for Immune Cell Subsets at Single-cell Resolution

Emma Kuan (Allen Institute, USA)

Abstract
October 20(Sun)
15:10-16:50
Symposium 2

mRNA Vaccine and Immunity (Co-hosted by the IBS Korea Virus Research Institute Center for Viral Immunology)

Room B
Chair(s) Marion Pepper (Univ. of Washington, USA)
Kevin Kee-Jong Hong (Gachon University, College of Medicine, KOR)
15:10-15:35 Engineering immune responses through mRNA vaccination

David Alvarez (Moderna, USA)

Abstract
15:35-16:00 B cell responses to vaccination: lessons from the SARS-CoV-2 pandemic

Ali Ellebedy (Washington Univ., USA)

Abstract
16:00-16:25 COVID-19 vaccine - the journey of the mRNA technology in the global pandemic

Annette Vogel (BioNTech SE, DEU)

Abstract
16:25-16:37 Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection (2024 ICIS-Pfizer Trainee Award)

Benjamin Broomfield (The Walter and Eliza Hall Institute (WEHI), AUS)

Abstract
16:37-16:49 Type I IFN Driven IL-27 Promotes CD8+ T Cell Responses to LNP-mRNA Immunization

Anthony Phan (University of Pennsylvania, USA)

Abstract
October 20(Sun)
15:10-16:50
Symposium 3

Cytokine Signaling & Immune Modulation (Co-hosted by the Infection Control Convergence Medical Research Center)

Room C
Chair(s) Sandra Nicholson (Walter & Eliza Hall Institute, AUS)
Yeonseok Chung (Seoul National University, KOR)
15:10-15:22 Lymph Node Targeted Engineered IL-35 to Treat Autoimmunity and Inflammation

Jun Ishihara (Imperial College London, GBR)

Abstract
15:22-15:34 Temporally resolved prediction of phosphosites directing cytokine specificity

Rachel Gottschalk (University of Pittsburgh, USA)

Abstract
15:34-15:46 Defective maturation of the interleukin-11 receptor results in craniosynostosis

Christoph Garbers (Hannover Medical School (MHH), DEU)

Abstract
15:46-15:58 Candida albicans Extracellular Vesicles Trigger Type I IFN Signaling via cGAS and STING

Hannah Brown Harding (Massachusetts General Hospital/Harvard Medical School, USA)

Abstract
15:58-16:10 Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming

Kay Chung (University of North Carolina at Chapel Hill, USA)

Abstract
16:10-16:22 Tumor-infiltrating CD8+ T Cell Dynamics Distinctly Elicited by in situ FLT3L Expression and Immune Checkpoint Inhibition

Suk-Jo Kang (Korea Advanced Institute of Science and Technology (KAIST), KOR)

Abstract
16:22-16:34 Uncovering cell-type-specific immunomodulatory variants and associated molecular phenotypes in infectious disease using structurally-resolved protein networks

Jishnu Das (University of Pittsburgh, USA)

Abstract
October 20(Sun)
16:50-17:40
Keynote 1

Room A
Chair(s) You-Me Kim (KAIST, KOR)
16:50-17:40 Type 2 cytokines: a story of macrophages, matrix & metazoan parasites

Judith Allen (The Univ. of Manchester, GBR)

Abstract
October 20(Sun)
17:40-19:10
Poster 1

October 21(Mon)
08:30-10:10
Philip I. Marcus Memorial Symposium 4

Host-microbiota Interaction (Partly Sponsored by JICR / Mary Ann Liebert, Inc.)

Room A
Chair(s) David Woodland (Mary Ann Liebert, Inc, USA)
Kwang Soon Kim (POSTECH, KOR)
08:30-08:55 Wild-derived microbiota regulate host immune responses and disease outcome in preclinical models (2024 Philip I. Marcus Lecture)

Barbara Rehermann (NIH, USA)

Abstract
08:55-09:20 Microbiome therapeutics for inflammatory disorders and cancer

Sin-Hyeog Im (POSTECH, KOR)

Abstract
09:20-09:32 Microbiota-Responsive Innate-Like T-Cells are a Target of Immune Checkpoint Blockade in Cancer

Joseph Gladstone (Weill Cornell Medicine, USA)

Abstract
09:32-09:44 An Engineered Probiotic Produces a Type III Interferon IFNL1 and Reduces Inflammations in in vitro Inflammatory Bowel Disease Models

Koon Jiew Chua (National University of Singapore, Singapore)

Abstract
09:44-09:56 A multivalent, nucleoside modified mRNA-LNP vaccine protects against Clostridioides difficile infection

Alexa Semon (University of Pennsylvania and Children's Hospital of Philadelphia, USA)

Abstract
09:56-10:08 IL17 Signaling in Intestinal Epithelial Cells Regulates Host-Microbiota Interaction Controlling Neuroinflammation in Atherosclerosis

Ekaterina Koltsova (Cedars Sinai Medical Center, USA)

Abstract
October 21(Mon)
08:30-10:10
Symposium 5

B Cell and Cytokines

Room B
Chair(s) Ali Ellebedy (Washington Univ., USA)
Tae Jin Kim (Sungkyunkwan University, KOR)
08:30-08:55 Heterogeneous populations of allergen-specific CD4+ Trm in the lungs

Marion Pepper (Univ. of Washington, USA)

Abstract
08:55-09:20 The impact of type I interferon dynamics on memory B cell subsets during infection

Kim Good-Jacobson (Monash Univ., AUS)

Abstract
09:20-09:32 Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome

Hyun-Kyu Choi (Yonsei University, KOR)

Abstract
09:32-09:44 IL-33 expands plasma cells, disrupts germinal centers, and increases autoantibody production

Eva Conde Garcia (Regeneron Pharmaceuticals, USA)

Abstract
09:44-09:56 The Antibody and B cell Response to SARS-CoV-2 in Patients with Solid Cancers: The Importance of Age and Recent IV Cytotoxic Anti-cancer Therapy

Ji Eun Oh (Korea Advanced Institute of Science and Technology (KAIST), KOR)

Abstract
October 21(Mon)
08:30-10:10
Symposium 6

T-cell Subsets and Functions in Tissue Immunity (KAI-AKIA Joint Session)

Room C
Chair(s) Minsoo Kim (University of Rochester, USA)
Jeehee Youn (Hanyang University, KOR)
08:30-08:55 Unexpected role of Interleukin-17

Jun Huh (Harvard Univ., USA)

Abstract
08:55-09:20 CD103 preconditions naïve CD8 T cells for their acquisition of effector phenotype and function

Jung-Hyun Park (NIH/NCI, USA)

Abstract
09:20-09:45 The pathogenic and protective roles of virtual memory CD8 T cells

Su-Hyung Park (KAI Grand Achievement Award
Graduate School of Medical Science and Engineering, KAIST, KOR)

Abstract
09:45-10:10 CD8 T cell differentiation during persistent antigenic stimulation: Implications for immunotherapy (KAI-Seegene Medical Foundation Excellence Award)

Sejin Im (KAI-Seegene Medical Foundation Excellence Award
Sungkyunkwan University School of Medicine, KOR)

Abstract
October 21(Mon)
10:10-10:40
Coffee Break

October 21(Mon)
10:40-12:00
Symposium 7

Trained Immunity and Immunometabolism

Room A
Chair(s) Susan Carpenter (UCSC, USA)
Sungho Park (UNIST, KOR)
10:40-11:05 Central trained immunity and chronic inflammation

George Hajishengallis (Univ. of Pennsylvania, USA)

Abstract
11:05-11:30 Targeting innate immune memory in diseases of the aging eye

Przemyslaw Sapieha (Centre de recherche HMR, CAN)

Abstract
11:30-11:42 Control of Macrophage Inflammatory Responses by the HDAC7-RL5P-NRF2 Axis

Divya Ramnath (The University of Queensland, AUS)

Abstract
11:42-11:54 Lipid metabolic control of dendritic cell function in allergic asthma

Yeonseok Chung (Seoul National University, KOR)

Abstract
October 21(Mon)
10:40-12:00
Symposium 8

Mucosal Immunity

Room B
Chair(s) Barbara Rehermann (NIH, USA)
Sin-Hyeog Im (POSTECH, KOR)
10:40-11:05 Neutrophil heterogeneity at steady state and stress conditions

Lai Guan Ng (Shanghai Immune Therapy Institute, Shanghai, CHN)

Abstract
11:05-11:30 The first mucosal barrier: stomach immunity as a key regulator

Naoko Satoh-Takayama (RIKEN, JPN)

Abstract
11:30-11:42 IL-10 Family Cytokines in Gastrointestinal Graft-versus-Host Disease (2024 ICIS-Pfizer Trainee Award)

Amir Shamshirian (QIMR Berghofer Medical Research Institute, AUS)

Abstract
11:42-11:54 Interplay of Escherichia coli Infection with Zinc Deficiency or Th1 Blockade Induces Oral Lichen Planus-Like Histopathology in Mice

Youngnim Choi (Seoul National University, KOR)

Abstract
October 21(Mon)
10:40-12:00
Symposium 9

T Cell Homeostasis and Cytokines (Charles D. Surh Memorial Session)

Room C
Chair(s) Jonathan Sprent (Garvan Institute of Medical Research, AUS)
Dong Sup Lee (Seoul National University, College of Medicine, KOR)
10:40-10:50 Introduction to Charles D Surh memorial session

Jonathan Sprent (Garvan Institute of Medical Research, AUS)

Abstract
10:50-11:15 Fixing to generate new T cells (lessons learned from Charlie Surh, about golf, wine & cytokines)

Juan Carlos Zuniga-Pflucker (Univ. of Toronto, CAN)

Abstract
11:15-11:35 Subsetting and shaping naive CD8 T cell pools with complex effector codes

Jae Ho Cho (Chonnam Univ, KOR)

Abstract
11:35-11:47 Understanding CD4+ T cell response to food antigens

Sung Wook Hong (Yonsei Univ, KOR)

Abstract
11:47-11:59 Unravelling the mechanisms behind the single clade predominance of Akkermansia muciniphila

Kwang Soon Kim (POSTECH, KOR)

Abstract
October 21(Mon)
12:00-13:00
Lunch Break

October 21(Mon)
13:00-14:30
Poster 2

October 21(Mon)
14:30-15:20
Lightning Talks 1

Infection and Immunity

Room A
Chair(s) Carolina Lucas (School of Medicine, Yale University, USA)
Doo-Jin Kim (Chungbuk National University, KOR)
14:30-14:38 Epigenetic Scars in Regulatory T Cells among Patients with Chronic Hepatitis C Virus Infection

So-Young Kim (Korea Advanced Institute of Science and Technology (KAIST), KOR)

Abstract
14:38-14:46 Legionella triggers sequential pyroptosis and effector-triggered apoptosis in dendritic cells

Victor Vazquez Marrero (University of Pennsylvania, USA)

Abstract
14:46-14:54 Role of IFNgamma during Tuberculosis Infection in Mesenchymal Stem Cells

Shaina Jamwal (ICGEB, New Delhi, India)

Abstract
14:54-15:02 The Role of Splenic Stromal Cells in the Innate Immune Defense Against Infection

Andrzej Gruza (University of Veterinary Medicine Vienna, Austria)

Abstract
15:02-15:10 Effect of Latent MCMV Infection on the Development of Metabolic Dysfunction-associated Fatty Liver Disease

Woomi Jung (Korea Advanced Institute of Science and Technology (KAIST), KOR)

Abstract
15:10-15:18 Synergistic Cytokine Control of Antifungal Immunity in the Female Reproductive Tract

Melissa Cook (University of Pittsburgh, USA)

Abstract
October 21(Mon)
14:30-15:20
Lightning Talks 2

Mucosal Immunity and Microbiota

Room B
Chair(s) Melinda Engevik (Medical University of South Carolina, USA)
June-Yong Lee (Yonsei University College of Medicine, KOR)
14:30-14:38 Novel IL-23 Reporter Mice Reveals the Cellular And Molecular Regulation of IL-23 Production in Mucosal Host Defense

Daiya Ohara (Kyoto University, JPN)

Abstract
14:38-14:46 Dietary and circadian cues regulate gut barrier integrity by synchronizing epithelial cell-macrophage crosstalk

Chaitanya Dende (University of Texas Southwestern Medical Center, USA)

Abstract
14:46-14:54 ILC3-derived Prostaglandin Protects from Intestinal Inflammation and Damage

Veronika Horn (Weill Cornell Medicine, USA)

Abstract
14:54-15:02 Epidermal Blimp-1 Deficiency-Associated Barrier Dysfunction and Microbial Dysbiosis Cause Atopic Dermatitis-Like Skin Inflammation

Hao-Wen Yang (Academia Sinica, Taipei, Taiwan)

Abstract
15:02-15:10 Mechanisms Linking Low-Grade Bowel Inflammation with Delayed Intestinal Motility

Inna Afonina (VIB-UGent, Belgium)

Abstract
15:10-15:18 Virtual Memory T cells are Induced by Wild-Derived Microbiota in an IL-15-dependent Manner and Enhance the Response to Immune Checkpoint Inhibitor Therapy

Jihoon Oh (NIH / NIDDK, USA)

Abstract
October 21(Mon)
14:30-15:20
Lightning Talks 3

Inflammation and Cell Signaling

Room C
Chair(s) Jae-Hoon Choi (Hanyang University, KOR)
Sanghyun Lee (Brown Univ., USA)
14:30-14:38 Microglial NLRP3-Gasdermin D Activation Impairs Blood-Brain Barrier Integrity through Interleukin-1-Independent Neutrophil Chemotaxis upon Peripheral Inflammation

Sung-Hyun Yoon (Yonsei University College of Medicine, KOR)

Abstract
14:38-14:46 MARCH5 promotes NLRP3-NEK7 Complex Formation and Inflammasome Activation via ubiquitination of NLRP3

Kiramage Chathuranga (Chugnam National University, KOR)

Abstract
14:46-14:54 Uncovering the Neddylation of adaptor ASC action in the formation of speck and inflammaome activity

XUEFENG FEI (Shanghai Jiao Tong University School of Medicine, CHN)

Abstract
14:54-15:02 Itaconate Drives mtRNA-mediated Interferon Via Inhibition of Succinate Dehydrogenase

Shane O'Carroll (Trinity College Dublin, IRE)

Abstract
15:02-15:10 Mechanistic Insights into the Steroid-Sparing Potential of Toll-Like Receptor 7 and 8 Inhibition in Autoimmunity

Jia Xin Chow (Monash University, AUS)

Abstract
15:10-15:18 Differentiation and Activation of Monocytes/macrophages Induced by GM-CSF Signaling Exacerbates Synovial Inflammation in Autoimmune Arthritis

Hiroki Mukoyama (Institute for Life and Medical Sciences, Kyoto University, JPN)

Abstract
October 21(Mon)
15:20-15:50
Industry 1

Quality-based development of Biosimilar (Samsung Bioepis)

Room A
Chair(s) Ho Youn Kim (Catholic University, KOR)
15:20-15:50 Quality-based development of Biosimilar

Sang Hyun Baek (Samsung Bioepis, KOR)

Abstract
October 21(Mon)
15:20-15:50
Industry 2

Exploring IL-1β in AID (Novartis)

Room B
Chair(s) Dae-Chul Jeong (Seoul ST. Mary’s Hospital, KOR)
15:20-15:50 Role of IL-1β inhibition in auto-inflammatory disease

Seong-Heon Kim (Seoul National University Hospital , KOR)

Abstract
October 21(Mon)
15:50-16:20
Coffee Break

October 21(Mon)
16:20-18:00
Symposium 10

Tumor Immunology and Immunotherapy

Room A
Chair(s) Roza Nurieva (The University of Texas MD Anderson Cancer Center, USA)
Hun Sik Kim (University of Ulsan College of Medicine, KOR)
16:20-16:45 Modulating cytokine signaling to enhance efficacy and safety of CAR-T cell therapy

Yuki Kagoya (Keio Univ., JPN)

Abstract
16:45-17:10 Shared mechanisms of Anti-PD1 efficacy in tumor, and toxicity in tissue

Niroshana Anandasabapathy (Cornell Univ., USA)

Abstract
17:10-17:35 HLA-agnostic functional identification and therapeutic targeting of cancer neoantigens

Stephen Schoenberger (La Jolla Institute for Immunology, USA)

Abstract
17:35-17:47 Understand age-associated decline in antiviral T cell immunity (2024 ICIS-Regeneron New Investigator Awards for Excellence in Cytokine & Interferon Research)

Tuoqi Wu (University of Texas Southwestern Medical Center, USA)

Abstract
17:47-17:59 Immune Checkpoint Inhibitor-Mediated Colitis: Mechanistic Insights and Therapeutic Targets

Roza Nurieva (The University of Texas MD Anderson Cancer Center, USA)

Abstract
October 21(Mon)
16:20-18:00
Symposium 11

Infection and Inflammation (Co-hosted by the Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine)

Room B
Chair(s) Ram Savan ((Dept of) Immunology - University of Washington, USA)
Kellie Jurado (University of Pennsylvania, USA)
16:20-16:45 Differential innate antiviral signaling in human and bat cells

Karen Mossman (McMaster Univ., CAN)

Abstract
16:45-17:10 Regulation of IL-15-induced NK-like activation of CD8+ T cells in viral infection

Eui-Cheol Shin (KAIST, KOR)

Abstract
17:10-17:35 Inflammasome sensing in inflammation and cancer

Si Ming Man (Australia National Univ., AUS)

Abstract
17:35-17:47 Immunological misfiring in severe COVID-19 (2024 ICIS-Christina Fleischmann Award for Excellence in Cytokine & Interferon Research)

Carolina Lucas (School of Medicine, Yale University, USA)

Abstract
17:47-17:59 Lung dendritic cell metabolism underlies susceptibility to viral infection in diabetes (2024 Sidney & Joan Pestka Post-Graduate Award)

Samuel Philip Nobs (Weizmann Institute of Science, ISR)

Abstract
October 21(Mon)
16:20-18:00
Guest Symposium 1

Predicting Virus Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence- PreVAIL Kids Experience with SARS-CoV-2 Infection Syndrome Including MIS-C

Room C
Chair(s) Sai Majji (NIH/NICHD, USA)
Ananth Annapragada (Texas Children's Hospital, USA)
Juan Salazar (Connecticut Children's Hospital, USA)
16:20-16:30 PreVAIL kIds Program - Introduction, Overview and Summary

Sai Majji (NIH/NICHD, USA)

Abstract
16:30-16:45 Inflammatory profiles and clinical signatures of pediatric COVID-19

Ananth Annapragada (Texas Children's Hospital, USA)

Abstract
16:45-17:00 Diagnosing children with SARS-CoV-2 related illness

Jane Burns (University of California, San Diego, USA)

Abstract
17:00-17:15 Cell-free RNA profiling of plasma for differential diagnosis of hyperinflammatory syndromes in children

Charles Chiu (University of California, San Francisco, USA)

Abstract
17:15-17:30 A genetically modulated Toll-like-receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome

Maria Gennaro (Rutgers University, USA)

Abstract
17:30-17:45 Analytics approaches to evaluate the contribution of biomarkers integrated into clinical prediction models

Cedric Manlhiot (Johns Hopkins University, USA)

Abstract
17:45-18:00 Identifying biomarker signatures of prognostic value for Multisystem Inflammatory Syndrome in Children (MIS-C)

Juan Salazar (Connecticut Children's Hospital, USA)

Abstract
October 21(Mon)
18:30~21:00
Early Career Researcher (ECR) Networking

October 22(Tue)
08:30-10:10
Symposium 12

Engineered Cytokine and Immunotherapy

Room A
Chair(s) Brendan Jenkins (The University of Adelaide, AUS)
Yoon Park (Korea Institute of Science and Technology, KOR)
08:30-08:55 Molecular modulation of interleukin-2 for next-generation immunotherapy

Onur Boyman (Univ. of Zurich, CHE)

Abstract
08:55-09:20 Unraveling the mystery of IFNλ4 and its signaling complex utilizing computation, protein engineering, and cryoEM

Juan Mendoza (Univ Chicago, USA)

Abstract
09:20-09:45 New strategies of antibody based fusion proteins for tumor immunity

Yang-Xin Fu (Tsinghua Univ., CHN)

Abstract
09:45-09:57 STAT Rebalancing with Engineered Cytokines Restrains T Cell Exhaustion and Mitigates Toxicity

Grayson Rodriguez (Stanford University, USA)

Abstract
09:57-10:09 AttIL12-T Cell Therapy For Simultaneously Disrupting Stroma/tumors And Induction Of Endogenous TCR-T Cells

Shulin Li (The University of Texas MD Anderson Cancer Center, USA)

Abstract
October 22(Tue)
08:30-10:10
Symposium 13

Immune Regulation of Inflammatory Diseases (Partly Sponsored by Elsevier's Journal Cytokine)

Room B
Chair(s) Dhan Kalvakolanu (University of Maryland School of Medicine, USA)
Chang Ook Park (Yonsei University College of Medicine, KOR)
08:30-08:55 Transcription factor NFAT5 is essential to rheumatoid arthritis

Wan-Uk Kim (Catholic Univ., KOR)

Abstract
08:55-09:20 Metabolic checkpoints in autoimmune tissue inflammation

Cornelia M. Weyand (Mayo Clinic, USA)

Abstract
09:20-09:45 Mechanistic insights into glucocorticoid regulation of immune responsiveness at the MIF locus

Richard J. Bucala (Yale Univ. School of Medicine, USA)

Abstract
09:45-09:57 Cytokine and metabolic regulation of tissue Tregs at homeostasis and during obesity-associated inflammatory and metabolic diseases (2024 ICIS-Regeneron New Investigator Awards for Excellence in Cytokine & Interferon Research)

Chaoran Li (Emory University, USA)

Abstract
09:57-10:09 IL-38 Is A Novel Inhibitor Of The Pattern Recognition Receptor-Interferon Axis

Ina Rudloff (Hudson Institute of Medical Research, AUS)

Abstract
October 22(Tue)
08:30-10:10
Guest symposium 2

Stress Immune Responses and Homeostasis (by Japanese Cytokines Society)

Room C
Chair(s) Hiroki Yoshida (Saga University Faculty of Medicine, JPN)
Akinori Takaoka (Hokkaido University, JPN)
08:30-08:40 Introduction of JCS

Toshiaki Ohteki (Tokyo Medical and Dental University, JPN)

Abstract
08:40-08:58 Immune response in the central nervous system disease

Minako Ito (Medical Institute of Bioregulation Kyushu University, JPN)

Abstract
08:58-09:16 Generation and behavior of innate immune cells during systemic infection

Masashi Kanayama (Medical Research Institute, Tokyo Medical and Dental University, JPN)

Abstract
09:16-09:34 Memory CD8 T cells are vulnerable to chronic interferon-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice

Ruka Setoguchi (The University of Tokyo, JPN)

Abstract
09:34-09:52 Spatial diversity of the liver immune function and its significance

Yu Miyamoto (Osaka University Immunology Frontier Research Center, JPN)

Abstract
09:52-10:10 Mechanisms of colitis prevention following cecal resection

Kazuyo Moro (Osaka University, RIKEN, JPN)

Abstract
October 22(Tue)
10:10-10:40
Coffee Break

October 22(Tue)
10:40-12:00
Symposium 14

Cytokines and CD8 T Cell Immunity (Partly Sponsored by Trutino Biosciences)

Room A
Chair(s) David G Brooks (Univ. of Toronto, CAN)
Sang-Jun Ha (Yonsei University, KOR)
10:40-11:05 Retinoic acid and TGF-β orchestrate organ-specific programs of tissue-residency

Laura Mackay (2024 ICIS-Luminex John R. Kettman Award for Excellence in Cytokine & Interferon Research
Univ. of Melbourne, AUS)

Abstract
11:05-11:30 Costimulation modulates exhausted PD-1+ CD8 T cells beyond priming

Alice Kamphorst (Mount Sinai, USA)

Abstract
11:30-11:55 T cell differentiation and function in chronic infection and cancer

Axel Kallies (Univ. of Melbourne, AUS)

October 22(Tue)
10:40-12:00
Symposium 15

Cytokines and Myeloid Cells

Room B
Chair(s) Ivan Zanoni (Harvard Medical School, USA)
Keehoon Jung (Seoul National University, KOR)
10:40-11:05 Spatial and molecular control of tumor-associated macrophages

Renato Ostuni (Università Vita-Salute San Raffaele, ITA)

Abstract
11:05-11:17 Age-dependent inflammation is promoted by GDF3-SMAD2/3 signaling axis in adipose tissue macrophages (2024 ICIS-Pfizer Trainee Award)

In Hwa Jang (University of Minnesota, USA)

Abstract
11:17-11:42 Microbiota-regulation of tumor-associated macrophages

Jorge Henao-Mejia (Univ. of Pennsylvania, USA)

Abstract
11:42-11:54 Cancer Neutrophil Encyclopedia: A Deep Dive into Antigen-Presenting Warriors (2024 Sidney & Joan Pestka Graduate Award)

Ying Cheng Wu (Zhongshan Hospital Fudan University, CHN)

Abstract
October 22(Tue)
10:40-12:00
Symposium 16

Immune Regulation of Tissue Repair (Co-hosted by the Innate Immune-Mediated Chronic Inflammatory Disease Medical Research Center)

Room C
Chair(s) Snehlata Kumari (The University of Queensland, AUS)
YunJae Jung (Gachon University, KOR)
10:40-11:05 Fibroblast orchestration of tissue resident lymphocytes in disease and aging

Tien Peng (Univ. of California, San Francisco, USA)

Abstract
11:05-11:30 Unique mechanisms of early life inflammation

Shruti Naik (New York Univ., USA)

Abstract
11:30-11:42 Inflammatory niche in lung tissue regeneration and chronic diseases

Jinwook Choi (Gwangju Institute of Science and Technology (GIST), KOR)

Abstract
11:42-11:54 Tif1g regulates stability of regulatory T cells during inflammation (2024 ICIS-Pfizer Trainee Award)

Eugenio Contreras Castillo (National Autonomous University of Mexico, MEX)

Abstract
October 22(Tue)
12:00-13:00
Lunch Break

October 22(Tue)
13:00-14:30
Poster 3

October 22(Tue)
14:30-15:20
Lightning Talks 4

Tumor Immunology and Immunotherapy (Partly Sponsored by Regeneron)

Room A
Chair(s) Eva Conde Garcia (Regeneron Pharmaceuticals, USA)
Sejin Im (Sungkyunkwan University School of Medicine, KOR)
14:30-14:38 Enabling Immune Checkpoint Blockade Efficacy in T-lymphopenia by Restoring CD8 T cell Dynamics with IL-7 Cytokine Therapy

Yeon-Woo Kang (POSTECH, KOR)

Abstract
14:38-14:46 Targeting Nrf2 Enhances Anti-tumour Immune Response of CAR-T cells

Yuna Jo (Pusan National University School of Medicine, KOR)

Abstract
14:46-14:54 Infectious Bursal Disease Virus (IBDV) as a novel virotherapy for stimulating innate and adaptive immune responses in different murine cancer models.

Vicent Tur Planells (CEU San Pablo University, Spain)

Abstract
14:54-15:02 IL-9 Promotes Lung Tumor Growth by Intrinsic Regulation of Interstitial Macrophage Arginine Metabolism

Anthony Cannon (Indiana University School of Medicine, USA)

Abstract
15:02-15:10 Biological Mechanisms of IL-15 and IL-21-Augmented CAR T-Cell Therapy for Neuroblastoma

Natalia Yakobian (National Cancer Institute, USA)

Abstract
15:10-15:18 Tailoring T cell anti-tumor immunity in hepatocellular carcinoma by exploiting Kupffer cell-guided priming

Jaeoh Park (University of Lausanne, Switzerland)

Abstract
October 22(Tue)
14:30-15:20
Lightning Talks 5

Innate Immunity in Health and Diseases

Room B
Chair(s) Claudia Nold-Petry (The Ritchie Centre, Hudson Institute of Medical Research, Melbourne VIC, AUS)
Je-Wook Yu (Yonsei University, KOR)
14:30-14:38 Cholesterol metabolism in dendritic cells regulates neutrophilic asthma by controlling ER stress-PPARg balance

HAYEON CHUNG (Seoul National University, KOR)

Abstract
14:38-14:46 Dissecting The Role of Myeloid-Derived NLRP3 in a Murine Model of Silicosis

Kristian Barry (Hudson Institute of Medical Research, AUS)

Abstract
14:46-14:54 Regnase-1/3 controls hematopoietic lineage bias through degradation of Nfkbiz mRNA

Takuya Uehata (Graduate School of Medicine, Kyoto university, JPN)

Abstract
14:54-15:02 STK25 Regulates Myeloid Cell Trafficking and Effector Function during Injury and Inflammation

Bharati Matta (The Feinstein Institutes for Medical Research, Northwell Health, USA)

Abstract
15:02-15:10 Impact of cAMP reduction in myeloid cells on gut dysbiosis-induced attenuation of influenza virus immunity

Seongok Park (Jeonbuk National University, KOR)

Abstract
15:10-15:18 Bacterial and age-dependent inflammatory responses in BMDMs coinfected with Influenza virus and Streptococcus sp.

Extanislao Nistal Villan (Universidad San Pablo CEU, Spain)

Abstract
October 22(Tue)
14:30-15:20
Lightning Talks 6

Immune Regulation of Inflammatory Diseases

Room C
Chair(s) Kiyoshi Hirahara (Graduate School of Medicine, Chiba University, JPN)
Yoon-Seok Chang (Seoul National University Budang Hospital, KOR)
14:30-14:38 Intermittent Fasting Alleviates ILC2-mediated Type 2 Airway Inflammation

Young Jin Pyung (Seoul National University, KOR)

Abstract
14:38-14:46 Interferon Regulatory Factor 6 Determines Intestinal Epithelial Cell Development and Immunity

Austin Wright (Oregon Health & Science University, USA)

Abstract
14:46-14:54 Targeting the PD-1-FABP5 Axis Modulates Adipose Tissue ILC2 Metabolism in Obesity

Jongho Ham (Seoul National University, KOR)

Abstract
14:54-15:02 Ikzf1 Association With Foxp3 For Foxp3-dependent Gene Repression In Treg Cells: Disruption Of The Association Causes Autoimmunity

Kenji Ichiyama (Osaka University, JPN)

Abstract
15:02-15:10 Epithelial NF-kB coordinates type-17 immunity to initiate chronic inflammatory skin disease

Snehlata Kumari (The University of Queensland, AUS)

Abstract
15:10-15:18 Elucidating the Role of IFIH1 in Lupus Nephritis Pathogenesis

Jacquelyn Gorman (Oklahoma Medical Research Foundation, USA)

Abstract
October 22(Tue)
15:20-15:50
Industry 3

Emerging Therapeutics in Autoimmune Diseases (Abbvie)

Room A
Chair(s) Seung Cheol Shim (Chungnam National University, KOR)
15:20-15:50 JAK signaling in B cell activation and autoimmunity

Jason Jungsik Song (Yonsei University, KOR)

Abstract
October 22(Tue)
15:20-15:50
Industry 4

Tacrolimus and Autoimmune: From Mechanism to Clinical Practice (Astellas)

Room B
Chair(s) Jaeseok Yang (Yonsei University College of Medicine, Severance Hospital, KOR)
15:20-15:50 Mode of action of tacrolimus an autoimmune disease

Young Jae Park (Seoul St.Mary’s hospital, KOR)

Abstract
October 22(Tue)
15:50-16:20
Coffee Break

October 22(Tue)
16:20-18:00
Symposium 17

Type 2 Immunity and Airway Diseases (Partly Sponsored by the Society of Mucosal Immunology, SMI)

Room A
Chair(s) Elia Tait Wojno (University of Washington, USA)
Hyun-Woo Shin (Seoul National University, KOR)
16:20-16:45 Tfh cells and the antibody response to food allergens

Stephanie Eisenbarth (Northwestern Univ., USA)

Abstract
16:45-17:10 ILCs at the crossroads: understanding their influence in type 2 immunity and airway disorders

Hye-Young Kim (Seoul National Univ., KOR)

Abstract
17:10-17:35 The regulation and role lung resident and lymphoid T follicular helper cells in allergic airways disease

James Harker (Imperial College London, GBR)

17:35-17:47 Myeloid derived CXCL4 is required for optimal neutrophil recruitment into the lung during pulmonary allergic inflammation (2024 Pfizer-Amanda Proudfoot Tribute Award for Advances in Chemokine Biology by a Trainee)

Amanda Ridley (The University of Manchester, GBR)

Abstract
17:47-17:59 Th2 Cytokines Contribute to EoE Pathogenesis by Initiating STAT3/6-Mediated Mitochondria-Immune Signaling Axis

Jazmyne Jackson (Temple University, USA)

Abstract
October 22(Tue)
16:20-18:00
Symposium 18

Clinical Immunology of Autoimmune Diseases

Room B
Chair(s) Daniella Schwartz (University of Pittsburgh, USA)
Seung-Ki Kwok (Seoul St. Mary's Hospital, The Catholic University of Korea, KOR)
16:20-16:45 Mechanism-based cytokine-targeting therapies and precision medicine in rheumatic diseases

Yoshiya Tanaka (Univ. of Occupational and Environmental Health, JPN)

Abstract
16:45-17:10 The role of cytokine receptors in identifying T cell subsets in health and disease

Insoo Kang (Yale Univ. School of Medicine, USA)

Abstract
17:10-17:35 Integrative functional genomics reveals the determinants of Age/autoimmune-associated B Cells (ABCs)

Nan Shen (Shanghai Jiao Tong Univ. School of Medicine, CHN)

Abstract
17:35-17:47 RNA Host Response Profiling and Machine Learning for Differential Diagnosis of Acute Inflammatory Syndromes

Venice Servellita (University of California San Francisco, USA)

Abstract
17:47-17:59 IL-6 and IL-27 offer new insights into the development of disease heterogeneity in rheumatoid arthritis

Simon Jones (The School of Medicine, Cardiff University, GBR)

Abstract
October 22(Tue)
16:20-18:00
Guest Symposium 3

Lambda IFN

Room C
Chair(s) Ivan Zanoni (Harvard Medical School, USA)
Steeve Boulant (University of Florida, USA)
16:20-16:45 IFN-λ controls intestinal repair in IBD

Achille Broggi (CIML, FRA)

Abstract
16:45-17:10 Type III interferons (IFNλs) control intestinal epithelial barrier functions

Megan Stanifer (Univ. of Florida, USA)

Abstract
17:10-17:35 Single cell sequencing of influenza virus infected primary human alveolar macrophages reveals a powerful Interferon Lambda response

Rune Hartmann (Aarhus Univ., DNK)

Abstract
17:35-17:47 Viral exploitation of the programmed cell death for evasion of IFN-Lambda immunity

Sanghyun Lee (Brown Univ., USA)

Abstract
17:47-17:59 Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda

Tim Nice (OHSU, USA)

Abstract
October 23(Wed)
08:30-10:10
Symposium 19

Cytokine Dynamics in T Helper Cell Immune Regulation

Room A
Chair(s) Joanna Groom (WEHI, AUS)
Gap Ryol Lee (Sogang University, KOR)
08:30-08:55 Cytokines reorganize the 3D genome interactions in T cells

Golnaz Vahedi (Univ. of Pennsylvania, USA)

Abstract
08:55-09:20 Scratching exaggerates allergic inflammation and augments host defense via neurogenic mast cell activation

Daniel Kaplan (Univ. of Pittsburgh, USA)

Abstract
09:20-09:45 Non-canonical regulation of IL-21 bioavailability and activity

Di Yu (The Univ. of Queensland, AUS)

Abstract
09:45-09:57 A Th9-endotheliala activation loop promotes inflammatory cardiovascular disease (2024 ICIS-Regeneron New Investigator Awards for Excellence in Cytokine & Interferon Research)

Daniella M. Schwartz (University of Pittsburgh, USA)

Abstract
09:57-10:09 TGF-beta differentially specifies TFH/TH17 and TFR/Treg cell fates in murine CD4+ T cells through c-Maf

Dirk Baumjohann (University Hospital Bonn, DEU)

Abstract
October 23(Wed)
08:30-10:10
Symposium 20

Cytokine-mediated Translational Approaches of Human Diseases

Room B
Chair(s) Simon Jones (The School of Medicine, Cardiff University, GBR)
Chang-Hoon Kim (Yonsei University College of Medicine, KOR)
08:30-08:55 Anti-T2 biologics in severe asthma

Ian Adcock (Imperial College London, GBR)

Abstract
08:55-09:20 Role of CXCR6+CD4+ tissue-resident memory T cells in chronic allergic skin inflammation

Kenji Kabashima (Kyoto Univ., JPN)

Abstract
09:20-09:32 A Clinical Trial Combining a Tumor Targeting Immunocytokine (PDS01ADC) and Enzalutamide without Testosterone Lowering Therapy in Biochemically Recurrent Prostate Cancer

Ravi Madan (National Cancer Institute, USA)

Abstract
09:32-09:44 STAT3beta Represses Interferon Signaling and thereby Contributes to Favorable Outcomes in Acute Myeloid Leukemia

Sophie Edtmayer (Karl Landsteiner University of Health Sciences, AUT)

Abstract
09:44-09:56 Interferon Signature with Allograft Inflammatory Factor-1 Predicts TNF Inhibitor Response in Ankylosing Spondylitis

Jeong Seok Lee (KAIST, KOR)

Abstract
October 23(Wed)
08:30-10:10
Symposium 21

Cytokine Drug Development (Partly Sponsored by Coherus)

Room C
Chair(s) Juan Mendoza (Univ Chicago, USA)
Theresa LaVallee (Coherus BioSciences, USA)
08:30-08:42 Evaluation of CD25-biased IL-2m activity on non-Treg populations in vitro and in vivo

Kelly Remedios (Gilead, USA)

Abstract
08:42-08:54 Cell type-specific type I IFN antiviral response defines the neurotropism of Mpox virus

Oliver Harschnitz (Human Technopole, ITA)

Abstract
08:54-09:06 Pharmacodynamic Biomarkers of BMS-986326, a Novel IL-2/CD25 Fusion Protein That Induces Highly Selective and Durable Expansion of Regulatory T Cells Following Administration in Healthy Volunteers

Eun Mi Hur (Bristol Myers Squibb, USA)

Abstract
09:06-09:18 An Orthogonal IL-2/IL-2R-System Enhances Engineered T Cell Therapies Via a Highly Functional Synthetic Effector State and Obviates the Need for Lymphodepletion in Solid Tumors

PJ Aspuria (Synthekine, USA)

Abstract
09:18-09:30 The combination of NT-I7 and hIL-2/TCB2c promotes the development of an immune-stimulatory tumor microenvironment that enhances the anti-tumor efficacy in combination with checkpoint inhibitors

Minji Lee (NeoImmuneTech Co., Ltd., KOR)

Abstract
09:30-09:42 Development of Tuneable Cytokines via Tumor Stroma Sequestering Linkers

Phillip S. Kim (Trutino Biosciences, USA)

Abstract
09:42-09:54 A Novel Nanobody Based IL-18 Surrogate Cytokine Agonist, Used Alone or Combined with Immune Checkpoint Inhibitors, Demonstrated Synergistic Tumor Suppression in Xenograft mouse model

Yakun Wan (Shanghai Novamab Biopharmaceuticals Co., Ltd., CHN)

Abstract
October 23(Wed)
10:10-10:40
Coffee Break

October 23(Wed)
10:40-11:10
Industry 5

Inflammasome-activated Cytokines in Human Diseases (BMS)

Room A
Chair(s) Aisling O’Hara Hall (Bristol Myers Squibb, USA)
10:40-11:10 Inflammasome-activated cytokines in human diseases

Scott Canna (University of Pennsylvania Perelman School of Medicine, USA)

Abstract
October 23(Wed)
10:40-11:10
Industry 6

Filgotinib in the Treatment Algorithm of Rheumatoid Arthritis (Eisai Korea)

Room B
Chair(s) Eun Young Lee (Seoul National University Hospital, KOR)
10:40-11:10 Filgotinib in the treatment algorithm of rheumatoid arthritis

Jung Hee Koh (The Catholic Univ. of Korea, College of Medicine, KOR)

Abstract
October 23(Wed)
11:10-12:00
Lightning Talks 7

Cytokines and Human Diseases

Room A
Chair(s) Erik Lubberts (Erasmus MC, University Medical Center, NLD)
Seokchan Hong (University of Ulsan College of Medicine, Asan Medical Center, KOR)
11:10-11:18 CD25lowFoxp3+ T cells in small intestinal lamina propria contribute to rheumatoid arthritis pathogenicity by promoting conversion into pro-inflammatory Th17 cells

Sangwon Lee (College of Medicine, Gyeongsang National University, KOR)

Abstract
11:18-11:26 Pathophysiology of Dupilumab-Associated Head and Neck Dermatitis: An Integrated Analysis of Microbiome and Cytokinome

Wanjin Kim (Yonsei University College of Medicine, KOR)

Abstract
11:26-11:34 Novel Application of Established Arthritis Models Identifies Cytokine-Regulated Perturbations in Ocular Immune Homeostasis that Coincide with Arthritic Flares

Simon Eastham (University of Bristol, UK)

Abstract
11:34-11:42 HLA Class I-Downregulated Senescent Epidermal Basal Cells Orchestrate Skin Pathology in Systemic Lupus Erythematosus

Sena Yamamoto (Hokkaido University, JPN)

Abstract
11:42-11:50 Data Mining of IFNgamma-induced macrophage and Atherosclerotic Plaque Transcriptomes predicts a macrophage-specific role of STAT1 in human atherosclerosis

Natalia Lopacinska (Human Molecular Genetics Research Unit AMU, Poland)

Abstract
11:50-11:58 Investigation of the Pathogenesis of GM-CSF Autoantibodies Isolated from Patients with Cryptococcus Infection

Yu-Fang Lo (Chang-Gung University, Taiwan)

Abstract
October 23(Wed)
11:10-12:00
Lightning Talks 8

Cytokine Modulation of Adaptive Immunity

Room B
Chair(s) Dirk Baumjohann (University Hospital Bonn, DEU)
Youn Soo Choi (Seoul National University College of Medicine, KOR)
11:10-11:18 Deciphering the regulation of IL-2 signaling in T cells

Suyasha Roy (National Heart, Lung and Blood Institute, National Institutes of Health, USA)

Abstract
11:18-11:26 Epigenetic Regulators Of Clonal Hematopoiesis Control CD8 T cell Stemness During Immunotherapy

Tae Gun Kang (ST JUDE CHILDRENS RESEARCH HOSPITAL, USA)

Abstract
11:26-11:34 Interferon-Mediated Regulation of B-cell Responses to Viral Infection

Alana Kirn (Monash University, AUS)

Abstract
11:34-11:42 Bystander Th17 Activation And Its Functional Impact On Heterologous Challenge

Shweta Sabu (University of Zurich, Switzerland)

Abstract
11:42-11:50 The Multifaceted Nature of Tissue-Resident Memory T Cells in Healthy Organs

Hyun Jae Lee (The University of Melbourne, AUS)

Abstract
11:50-11:58 CIC-ATXN1L complex regulates marginal zone B cell development and sepsis via ETV4-Notch axis

Jongseok Park (POSTECH, KOR)

Abstract
October 23(Wed)
11:10-12:00
Lightning Talks 9

Cytokine Signaling and Regulation

Room C
Chair(s) Rachel Gottschalk (University of Pittsburgh, USA)
Ina Rudloff (Hudson Institute of Medical Research, AUS)
11:10-11:18 Preclinical Development of a 3rd Generation Interleukin-2 Targeted to Inflammatory Sites (IL-2IT)

Monica Cuevas Martinez (Sorbonne University, FRA)

Abstract
11:18-11:26 The alpha 2,8-disialyl Motif Modulates B-cell Receptor Signaling

Ho-Yang Tsai (Academia Sinica, Taiwan)

Abstract
11:26-11:34 Piezo1-mediated Mechanotransduction shapes ILC2s responses and Lung inflammatory pathways.

MinYeong Lim (Seoul National University, College of Medicine, KOR)

Abstract
11:34-11:42 IL-12 Signaling in Regulatory T Cells: like Protein Powder in Bodybuilding

Anna Estrada Brull (University of Zurich, Switzerland)

Abstract
11:42-11:50 IFI16 Regulates Cytokine-induced Responses in Human Keratinocytes Independent of a Role in DNA Sensing.

Marcin Baran (Trinity College Dublin, IRE)

Abstract
11:50-11:58 Modeling human mutations in mice reveals that a single amino acid in the STAT5B SH2 domain is critical for cytokine-induced enhancer activity.

Hye Kyung Lee (US National Institute of Health (NIH), USA)

Abstract
October 23(Wed)
12:00-13:30
Lunch Break

October 23(Wed)
13:30-14:30
Keynote 2

Room A
Chair(s) Sarah Gaffen (University of Pittsburgh, USA)
13:30-14:30 Nucleoside modified mRNA-LNP therapeutics

Drew Weissman (Univ. of Pennsylvania, USA)

Abstract
October 23(Wed)
14:30-15:00
Closing Session

Room A
Conference highlights & Closing remarks

Invitation to Cytokines 2025

October 23(Wed)
15:30-16:30
Transportation

October 23(Wed)
16:30-21:00
Gala Dinner

Go Top

Copyright ⓒ Cytokines 2024 & KAI 2024 Secretariat. All Rights Reserved.