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Cytokines 2024 KAI 2024

    
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Day 2
October 21(Mon)
08:30-10:10
Philip I. Marcus Memorial Symposium 4

Host-microbiota Interaction (Partly Sponsored by JICR / Mary Ann Liebert, Inc.)

Room A
Chair(s) David Woodland (Mary Ann Liebert, Inc, USA)
Kwang Soon Kim (POSTECH, KOR)
08:30-08:55 Wild-derived microbiota regulate host immune responses and disease outcome in preclinical models (2024 Philip I. Marcus Lecture)

Barbara Rehermann (NIH, USA)

Abstract
08:55-09:20 Microbiome therapeutics for inflammatory disorders and cancer

Sin-Hyeog Im (POSTECH, KOR)

Abstract
09:20-09:32 Microbiota-Responsive Innate-Like T-Cells are a Target of Immune Checkpoint Blockade in Cancer

Joseph Gladstone (Weill Cornell Medicine, USA)

Abstract
09:32-09:44 An Engineered Probiotic Produces a Type III Interferon IFNL1 and Reduces Inflammations in in vitro Inflammatory Bowel Disease Models

Koon Jiew Chua (National University of Singapore, Singapore)

Abstract
09:44-09:56 A multivalent, nucleoside modified mRNA-LNP vaccine protects against Clostridioides difficile infection

Alexa Semon (University of Pennsylvania and Children's Hospital of Philadelphia, USA)

Abstract
09:56-10:08 IL17 Signaling in Intestinal Epithelial Cells Regulates Host-Microbiota Interaction Controlling Neuroinflammation in Atherosclerosis

Ekaterina Koltsova (Cedars Sinai Medical Center, USA)

Abstract
October 21(Mon)
08:30-10:10
Symposium 5

B Cell and Cytokines

Room B
Chair(s) Ali Ellebedy (Washington Univ., USA)
Tae Jin Kim (Sungkyunkwan University, KOR)
08:30-08:55 Heterogeneous populations of allergen-specific CD4+ Trm in the lungs

Marion Pepper (Univ. of Washington, USA)

Abstract
08:55-09:20 The impact of type I interferon dynamics on memory B cell subsets during infection

Kim Good-Jacobson (Monash Univ., AUS)

Abstract
09:20-09:32 Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome

Hyun-Kyu Choi (Yonsei University, KOR)

Abstract
09:32-09:44 IL-33 expands plasma cells, disrupts germinal centers, and increases autoantibody production

Eva Conde Garcia (Regeneron Pharmaceuticals, USA)

Abstract
09:44-09:56 The Antibody and B cell Response to SARS-CoV-2 in Patients with Solid Cancers: The Importance of Age and Recent IV Cytotoxic Anti-cancer Therapy

Ji Eun Oh (Korea Advanced Institute of Science and Technology (KAIST), KOR)

Abstract
October 21(Mon)
08:30-10:10
Symposium 6

T-cell Subsets and Functions in Tissue Immunity (KAI-AKIA Joint Session)

Room C
Chair(s) Minsoo Kim (University of Rochester, USA)
Jeehee Youn (Hanyang University, KOR)
08:30-08:55 Unexpected role of Interleukin-17

Jun Huh (Harvard Univ., USA)

Abstract
08:55-09:20 CD103 preconditions naïve CD8 T cells for their acquisition of effector phenotype and function

Jung-Hyun Park (NIH/NCI, USA)

Abstract
09:20-09:45 The pathogenic and protective roles of virtual memory CD8 T cells

Su-Hyung Park (KAI Grand Achievement Award
Graduate School of Medical Science and Engineering, KAIST, KOR)

Abstract
09:45-10:10 CD8 T cell differentiation during persistent antigenic stimulation: Implications for immunotherapy (KAI-Seegene Medical Foundation Excellence Award)

Sejin Im (KAI-Seegene Medical Foundation Excellence Award
Sungkyunkwan University School of Medicine, KOR)

Abstract
October 21(Mon)
10:10-10:40
Coffee Break

October 21(Mon)
10:40-12:00
Symposium 7

Trained Immunity and Immunometabolism

Room A
Chair(s) Susan Carpenter (UCSC, USA)
Sungho Park (UNIST, KOR)
10:40-11:05 Central trained immunity and chronic inflammation

George Hajishengallis (Univ. of Pennsylvania, USA)

Abstract
11:05-11:30 Targeting innate immune memory in diseases of the aging eye

Przemyslaw Sapieha (Centre de recherche HMR, CAN)

Abstract
11:30-11:42 Control of Macrophage Inflammatory Responses by the HDAC7-RL5P-NRF2 Axis

Divya Ramnath (The University of Queensland, AUS)

Abstract
11:42-11:54 Lipid metabolic control of dendritic cell function in allergic asthma

Yeonseok Chung (Seoul National University, KOR)

Abstract
October 21(Mon)
10:40-12:00
Symposium 8

Mucosal Immunity

Room B
Chair(s) Barbara Rehermann (NIH, USA)
Sin-Hyeog Im (POSTECH, KOR)
10:40-11:05 Neutrophil heterogeneity at steady state and stress conditions

Lai Guan Ng (Shanghai Immune Therapy Institute, Shanghai, CHN)

Abstract
11:05-11:30 The first mucosal barrier: stomach immunity as a key regulator

Naoko Satoh-Takayama (RIKEN, JPN)

Abstract
11:30-11:42 IL-10 Family Cytokines in Gastrointestinal Graft-versus-Host Disease (2024 ICIS-Pfizer Trainee Award)

Amir Shamshirian (QIMR Berghofer Medical Research Institute, AUS)

Abstract
11:42-11:54 Interplay of Escherichia coli Infection with Zinc Deficiency or Th1 Blockade Induces Oral Lichen Planus-Like Histopathology in Mice

Youngnim Choi (Seoul National University, KOR)

Abstract
October 21(Mon)
10:40-12:00
Symposium 9

T Cell Homeostasis and Cytokines (Charles D. Surh Memorial Session)

Room C
Chair(s) Jonathan Sprent (Garvan Institute of Medical Research, AUS)
Dong Sup Lee (Seoul National University, College of Medicine, KOR)
10:40-10:50 Introduction to Charles D Surh memorial session

Jonathan Sprent (Garvan Institute of Medical Research, AUS)

Abstract
10:50-11:15 Fixing to generate new T cells (lessons learned from Charlie Surh, about golf, wine & cytokines)

Juan Carlos Zuniga-Pflucker (Univ. of Toronto, CAN)

Abstract
11:15-11:35 Subsetting and shaping naive CD8 T cell pools with complex effector codes

Jae Ho Cho (Chonnam Univ, KOR)

Abstract
11:35-11:47 Understanding CD4+ T cell response to food antigens

Sung Wook Hong (Yonsei Univ, KOR)

Abstract
11:47-11:59 Unravelling the mechanisms behind the single clade predominance of Akkermansia muciniphila

Kwang Soon Kim (POSTECH, KOR)

Abstract
October 21(Mon)
12:00-13:00
Lunch Break

October 21(Mon)
13:00-14:30
Poster 2

October 21(Mon)
14:30-15:20
Lightning Talks 1

Infection and Immunity

Room A
Chair(s) Carolina Lucas (School of Medicine, Yale University, USA)
Doo-Jin Kim (Chungbuk National University, KOR)
14:30-14:38 Epigenetic Scars in Regulatory T Cells among Patients with Chronic Hepatitis C Virus Infection

So-Young Kim (Korea Advanced Institute of Science and Technology (KAIST), KOR)

Abstract
14:38-14:46 Legionella triggers sequential pyroptosis and effector-triggered apoptosis in dendritic cells

Victor Vazquez Marrero (University of Pennsylvania, USA)

Abstract
14:46-14:54 Role of IFNgamma during Tuberculosis Infection in Mesenchymal Stem Cells

Shaina Jamwal (ICGEB, New Delhi, India)

Abstract
14:54-15:02 The Role of Splenic Stromal Cells in the Innate Immune Defense Against Infection

Andrzej Gruza (University of Veterinary Medicine Vienna, Austria)

Abstract
15:02-15:10 Effect of Latent MCMV Infection on the Development of Metabolic Dysfunction-associated Fatty Liver Disease

Woomi Jung (Korea Advanced Institute of Science and Technology (KAIST), KOR)

Abstract
15:10-15:18 Synergistic Cytokine Control of Antifungal Immunity in the Female Reproductive Tract

Melissa Cook (University of Pittsburgh, USA)

Abstract
October 21(Mon)
14:30-15:20
Lightning Talks 2

Mucosal Immunity and Microbiota

Room B
Chair(s) Melinda Engevik (Medical University of South Carolina, USA)
June-Yong Lee (Yonsei University College of Medicine, KOR)
14:30-14:38 Novel IL-23 Reporter Mice Reveals the Cellular And Molecular Regulation of IL-23 Production in Mucosal Host Defense

Daiya Ohara (Kyoto University, JPN)

Abstract
14:38-14:46 Dietary and circadian cues regulate gut barrier integrity by synchronizing epithelial cell-macrophage crosstalk

Chaitanya Dende (University of Texas Southwestern Medical Center, USA)

Abstract
14:46-14:54 ILC3-derived Prostaglandin Protects from Intestinal Inflammation and Damage

Veronika Horn (Weill Cornell Medicine, USA)

Abstract
14:54-15:02 Epidermal Blimp-1 Deficiency-Associated Barrier Dysfunction and Microbial Dysbiosis Cause Atopic Dermatitis-Like Skin Inflammation

Hao-Wen Yang (Academia Sinica, Taipei, Taiwan)

Abstract
15:02-15:10 Mechanisms Linking Low-Grade Bowel Inflammation with Delayed Intestinal Motility

Inna Afonina (VIB-UGent, Belgium)

Abstract
15:10-15:18 Virtual Memory T cells are Induced by Wild-Derived Microbiota in an IL-15-dependent Manner and Enhance the Response to Immune Checkpoint Inhibitor Therapy

Jihoon Oh (NIH / NIDDK, USA)

Abstract
October 21(Mon)
14:30-15:20
Lightning Talks 3

Inflammation and Cell Signaling

Room C
Chair(s) Jae-Hoon Choi (Hanyang University, KOR)
Sanghyun Lee (Brown Univ., USA)
14:30-14:38 Microglial NLRP3-Gasdermin D Activation Impairs Blood-Brain Barrier Integrity through Interleukin-1-Independent Neutrophil Chemotaxis upon Peripheral Inflammation

Sung-Hyun Yoon (Yonsei University College of Medicine, KOR)

Abstract
14:38-14:46 MARCH5 promotes NLRP3-NEK7 Complex Formation and Inflammasome Activation via ubiquitination of NLRP3

Kiramage Chathuranga (Chugnam National University, KOR)

Abstract
14:46-14:54 Uncovering the Neddylation of adaptor ASC action in the formation of speck and inflammaome activity

XUEFENG FEI (Shanghai Jiao Tong University School of Medicine, CHN)

Abstract
14:54-15:02 Itaconate Drives mtRNA-mediated Interferon Via Inhibition of Succinate Dehydrogenase

Shane O'Carroll (Trinity College Dublin, IRE)

Abstract
15:02-15:10 Mechanistic Insights into the Steroid-Sparing Potential of Toll-Like Receptor 7 and 8 Inhibition in Autoimmunity

Jia Xin Chow (Monash University, AUS)

Abstract
15:10-15:18 Differentiation and Activation of Monocytes/macrophages Induced by GM-CSF Signaling Exacerbates Synovial Inflammation in Autoimmune Arthritis

Hiroki Mukoyama (Institute for Life and Medical Sciences, Kyoto University, JPN)

Abstract
October 21(Mon)
15:20-15:50
Industry 1

Quality-based development of Biosimilar (Samsung Bioepis)

Room A
Chair(s) Ho Youn Kim (Catholic University, KOR)
15:20-15:50 Quality-based development of Biosimilar

Sang Hyun Baek (Samsung Bioepis, KOR)

Abstract
October 21(Mon)
15:20-15:50
Industry 2

Exploring IL-1β in AID (Novartis)

Room B
Chair(s) Dae-Chul Jeong (Seoul ST. Mary’s Hospital, KOR)
15:20-15:50 Role of IL-1β inhibition in auto-inflammatory disease

Seong-Heon Kim (Seoul National University Hospital , KOR)

Abstract
October 21(Mon)
15:50-16:20
Coffee Break

October 21(Mon)
16:20-18:00
Symposium 10

Tumor Immunology and Immunotherapy

Room A
Chair(s) Roza Nurieva (The University of Texas MD Anderson Cancer Center, USA)
Hun Sik Kim (University of Ulsan College of Medicine, KOR)
16:20-16:45 Modulating cytokine signaling to enhance efficacy and safety of CAR-T cell therapy

Yuki Kagoya (Keio Univ., JPN)

Abstract
16:45-17:10 Shared mechanisms of Anti-PD1 efficacy in tumor, and toxicity in tissue

Niroshana Anandasabapathy (Cornell Univ., USA)

Abstract
17:10-17:35 HLA-agnostic functional identification and therapeutic targeting of cancer neoantigens

Stephen Schoenberger (La Jolla Institute for Immunology, USA)

Abstract
17:35-17:47 Understand age-associated decline in antiviral T cell immunity (2024 ICIS-Regeneron New Investigator Awards for Excellence in Cytokine & Interferon Research)

Tuoqi Wu (University of Texas Southwestern Medical Center, USA)

Abstract
17:47-17:59 Immune Checkpoint Inhibitor-Mediated Colitis: Mechanistic Insights and Therapeutic Targets

Roza Nurieva (The University of Texas MD Anderson Cancer Center, USA)

Abstract
October 21(Mon)
16:20-18:00
Symposium 11

Infection and Inflammation (Co-hosted by the Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine)

Room B
Chair(s) Ram Savan ((Dept of) Immunology - University of Washington, USA)
Kellie Jurado (University of Pennsylvania, USA)
16:20-16:45 Differential innate antiviral signaling in human and bat cells

Karen Mossman (McMaster Univ., CAN)

Abstract
16:45-17:10 Regulation of IL-15-induced NK-like activation of CD8+ T cells in viral infection

Eui-Cheol Shin (KAIST, KOR)

Abstract
17:10-17:35 Inflammasome sensing in inflammation and cancer

Si Ming Man (Australia National Univ., AUS)

Abstract
17:35-17:47 Immunological misfiring in severe COVID-19 (2024 ICIS-Christina Fleischmann Award for Excellence in Cytokine & Interferon Research)

Carolina Lucas (School of Medicine, Yale University, USA)

Abstract
17:47-17:59 Lung dendritic cell metabolism underlies susceptibility to viral infection in diabetes (2024 Sidney & Joan Pestka Post-Graduate Award)

Samuel Philip Nobs (Weizmann Institute of Science, ISR)

Abstract
October 21(Mon)
16:20-18:00
Guest Symposium 1

Predicting Virus Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence- PreVAIL Kids Experience with SARS-CoV-2 Infection Syndrome Including MIS-C

Room C
Chair(s) Sai Majji (NIH/NICHD, USA)
Ananth Annapragada (Texas Children's Hospital, USA)
Juan Salazar (Connecticut Children's Hospital, USA)
16:20-16:30 PreVAIL kIds Program - Introduction, Overview and Summary

Sai Majji (NIH/NICHD, USA)

Abstract
16:30-16:45 Inflammatory profiles and clinical signatures of pediatric COVID-19

Ananth Annapragada (Texas Children's Hospital, USA)

Abstract
16:45-17:00 Diagnosing children with SARS-CoV-2 related illness

Jane Burns (University of California, San Diego, USA)

Abstract
17:00-17:15 Cell-free RNA profiling of plasma for differential diagnosis of hyperinflammatory syndromes in children

Charles Chiu (University of California, San Francisco, USA)

Abstract
17:15-17:30 A genetically modulated Toll-like-receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome

Maria Gennaro (Rutgers University, USA)

Abstract
17:30-17:45 Analytics approaches to evaluate the contribution of biomarkers integrated into clinical prediction models

Cedric Manlhiot (Johns Hopkins University, USA)

Abstract
17:45-18:00 Identifying biomarker signatures of prognostic value for Multisystem Inflammatory Syndrome in Children (MIS-C)

Juan Salazar (Connecticut Children's Hospital, USA)

Abstract
October 21(Mon)
18:30~21:00
Early Career Researcher (ECR) Networking

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